Finding disease candidate genes by liquid association
نویسندگان
چکیده
منابع مشابه
Association of Candidate Single Nucleotide Polymorphisms Related to Candidate Genes in Patients With Schizophrenia
Introduction: Schizophrenia is a chronic heterogenic neurodevelopment disorder. Many genes interfere in the development of SCZ. All four genes, NrCAM, PRODH, ANK3, and ANKK1, which were evaluated in this study, were previously reported to be associated with Schizophrenia. The NrCAM contributes to creating cognitive deficiencies through the CAM’s signaling pathway. PRODH plays a vital role in cr...
متن کاملPrioritizing candidate disease genes by network-based boosting of genome-wide association data.
Network "guilt by association" (GBA) is a proven approach for identifying novel disease genes based on the observation that similar mutational phenotypes arise from functionally related genes. In principle, this approach could account even for nonadditive genetic interactions, which underlie the synergistic combinations of mutations often linked to complex diseases. Here, we analyze a large-sca...
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Material Supplemental http://genome.cshlp.org/content/suppl/2011/04/28/gr.118992.110.DC1.html P<P Published online May 2, 2011 in advance of the print journal. Preprint Accepted likely to differ from the final, published version. Peer-reviewed and accepted for publication but not copyedited or typeset; preprint is service Email alerting click here top right corner of the article or Receive free...
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We have developed an integrated database that is specialized for the study of imprinted disease genes. The database contains novel candidate imprinted genes identified by the RIKEN full-length mouse cDNA microarray study, information on validated single nucleotide polymorphisms (SNPs) to confirm imprinting using reciprocal mouse crosses and the predicted physical position of imprinting-related ...
متن کاملno evidence for association between amelogenesis imperfecta and candidate genes
background: amelogenesis imperfecta (ai) is an inherited tooth disorder. despite the fact that up to now, several gene mutations in mmp20, enam, amelx and klk4 genes have been reported to be associated with ai, many other genes suggested to be involved. the main objective of this study was to find the mutations in three major candidate genes including mmp20, enam and klk4 responsible for ai f...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2007
ISSN: 1465-6906
DOI: 10.1186/gb-2007-8-10-r205